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Document 2649
DOCN M94A2649
TI Paediatric HIV diagnosis in the Malaysian context.
DT 9412
AU Sinniah M; Institute for Medical Research, Kuala Lumpur, Malaysia.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):256 (abstract no. PB0454). Unique
Identifier : AIDSLINE ICA10/94369926
AB OBJECTIVE: To evaluate diagnostic approaches for paediatric HIV
laboratory diagnosis in order to adopt the most suitable for use in the
Malaysian setting. MATERIALS & METHODS: Sera from babies suspected to be
HIV infected or born to HIV positive mothers were tested using Anti HIV
1 & 2 Elisa, HIV-Antigen Elisa and PCR. Follow up sera were tested where
available. RESULTS: All the 17 babies in our study had HIV Antibodies.
Diagnosis was established in most cases by persisting antibody levels at
follow-up; by PCR when that became available locally, and by a positive
HIV-Ag assay in only some of the cases. DISCUSSION & CONCLUSION: A
combination of tests seems suitable in the Malaysian context, due to the
technical difficulties inherent in these assays, as well as due to
sociocultural factors leading to defaulted follow-up.
DE *Developing Countries Enzyme-Linked Immunosorbent Assay Female
Follow-Up Studies Human HIV Antibodies/BLOOD HIV Antigens/BLOOD HIV
Infections/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION Infant Infant, Newborn
Malaysia Polymerase Chain Reaction Pregnancy MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).